Bmp4 gene expression

Bmp4 (Bone morphogenetic protein 4) – MGI gene detail Description: Bmp4 is expressed in both epithelium and mesenchyme at E12.5. Its expression is restricted to the mesenchyme from E13.5. Bmp4 is expressed only in the anterior and distal regions of the palatal shelves. Source: Zhang et al. (2002) Rescue of cleft palate in Msx1-deficient mice by transgenic…Continue Reading Bmp4 gene expression

Dlx5 gene expression

Dlx5 (Distal-less homeobox 5) – MGI gene detail Description: Dlx5 is expressed in the nasal mesenchyme along the AP axis of the E13.5 palatal shelf. Source: Han et al., 2009 Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development 136(24):4225-33….Continue Reading Dlx5 gene expression

Fgf9 gene expression

Fgf9 (Fibroblast growth factor 9) – MGI gene detail Description: Fgf9 is expressed in the palatal epithelium along the AP axis at E13.5. At E14.5, Fgf9 is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. Source: Iwata et al. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth…Continue Reading Fgf9 gene expression

Gli1 gene expression

Gli1 – MGI gene detail Description: Gli1 is expressed in the oral mesenchyme and oral epithelium along the AP axis at E13.5. At E14.5, expression is restricted to the oral mesenchyme of the anterior region of the palate. Sources: Han et al. (2009) Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate…Continue Reading Gli1 gene expression

P-SMAD1/5/8

Phospho-SMAD 1/5/8 – MGI gene detail for Smad1, 5, 8 Description: Activation of BMP signaling is observed in the nasal mesenchyme of the palatal shelves at E13.5 and E14.5 along the AP axis. A few P-SMAD1/5/8-positive cells in the oral and nasal epithelia are also detectable (not depicted here). Source: Han et al. (2009) Indirect modulation…Continue Reading P-SMAD1/5/8