Month: August 2011

Tgfb3 gene expression

Tgfb3 (Transforming growth factor beta 3) – MGI gene detail Description: Tgfb3 is expressed in the midline epithelium before the palatal shelves have contact in the midline (E14.0) until the complete disappearance of the MEE (E15.5). Sources:  Yang LT, Li LY & Kaartinen V, 2008. Tissue-specific expression of Cre recombinase from the Tgfb3 locus. Genesis 46(2):112-8. Jackson…Continue Reading Tgfb3 gene expression

Microarray: E14.5 Tgfbr2 Palate

Whole-genome transcriptome profiling by microarray of palatal tissue of E14.5 murine embryos with and without a conditional inactivation of Tgfbr2 in the cranial neural crest See a heatmap of the top 10 most differentially expressed genes between mutant and control samples for the following signaling pathways: BMP/TGF-Beta signaling pathway FGF signaling pathway Hedgehog signaling pathway Wnt…Continue Reading Microarray: E14.5 Tgfbr2 Palate

Tbx1 gene expression

Tbx1 (T-box 1) – MGI gene detail Description: At E12.5, Tbx1 expression appears in the epithelium of the most posterior domain of the palatal shelf. Tbx1 is expressed in the medial and posterior edge of the secondary palate before and after fusion. Sources: Funato et al. (2012) Tbx1 regulates oral epithelial adhesion and palatal development. Hum. Mol. Genet. 21(11):2524-37….Continue Reading Tbx1 gene expression