Dlx5 (Distal-less homeobox 5) – MGI gene detail Description: Dlx5 is expressed in the nasal mesenchyme along the AP axis of the E13.5 palatal shelf. Source: Han et al., 2009 Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development 136(24):4225-33….Continue Reading Dlx5 gene expression
Year: 2012
Microarray: E13.5 Erk2 Tongue
Whole-Genome Transcriptome Profiling by Microarray of Tongue Tissue of E13.5 Murine Embryos With and Without a Conditional Inactivation of Erk2 in the Cranial Neural Crest. See a heatmap of the top 10 most differentially expressed genes between mutant and control samples for the following signaling pathways: BMP/TGF-Beta signaling pathway FGF signaling pathway Hedgehog signaling pathway…Continue Reading Microarray: E13.5 Erk2 Tongue
Microarray: E13.5 Erk2 Palate
Whole-Genome Transcriptome Profiling by Microarray of Palatal Tissue of E13.5 Murine Embryos with and without a conditional inactivation of Erk2 in the cranial neural crest. See a heatmap of the top 10 most differentially expressed genes between mutant and control samples for the following signaling pathways: BMP/TGF-Beta signaling pathway FGF signaling pathway Hedgehog signaling pathway…Continue Reading Microarray: E13.5 Erk2 Palate
Microarray: E12.5 Erk2 Mandible
Whole-genome transcriptome profiling my microarray of mandibular tissue of E12.5 murine embryos with and without a conditional inactivation of Erk2 in the cranial neural crest See a heatmap of the top 10 most differentially expressed genes between mutant and control samples for the following signaling pathways: BMP/TGF-Beta signaling pathway FGF signaling pathway Hedgehog signaling pathway Wnt…Continue Reading Microarray: E12.5 Erk2 Mandible
Fgf10 gene expression
Fgf10 (Fibroblast growth factor 10) – MGI gene detail Description: Fgf10 is expressed in the mesenchyme of the anterior region of the developing palate and it is restricted to the oral side. Source: Alappat et al. (2005) The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev Biol 277(1): 102-13….Continue Reading Fgf10 gene expression
Fgfr2 gene expression
Fgfr2 (Fibroblast growth factor receptor 2) – MGI gene detail Description: Fgfr2 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE. It is also expressed in the nasal mesenchyme at E13.5 only in the posterior region of the palatal shelf. Source: Snyder-Warwick et…Continue Reading Fgfr2 gene expression
Fgf9 gene expression
Fgf9 (Fibroblast growth factor 9) – MGI gene detail Description: Fgf9 is expressed in the palatal epithelium along the AP axis at E13.5. At E14.5, Fgf9 is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. Source: Iwata et al. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth…Continue Reading Fgf9 gene expression
Fgf7 gene expression
Fgf7 (Fibroblast growth factor 7) – MGI gene detail Description: At E12.5 and E13.5, Fgf7 is expressed in the mesenchyme along the AP axis and it is restricted to the nasal side. At E14.5, Fgf7 is expressed along the AP and ON axes of the palate. Sources: Han et al., 2009 Indirect modulation of Shh signaling by…Continue Reading Fgf7 gene expression
Gli1 gene expression
Gli1 – MGI gene detail Description: Gli1 is expressed in the oral mesenchyme and oral epithelium along the AP axis at E13.5. At E14.5, expression is restricted to the oral mesenchyme of the anterior region of the palate. Sources: Han et al. (2009) Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate…Continue Reading Gli1 gene expression
Irf6 gene expression
Irf6 (Interferon regulatory factor 6) – MGI gene detail Description: Irf6 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE from E14.5 to E15.5. Source: Immunofluorescence. Unpublished data from Chai’s lab….Continue Reading Irf6 gene expression