Craniofacial phenotype analysis: Wnt1-Cre;Tgfbr2fl/fl

Genotype Wnt1-Cre;Tgfbr2fl/fl
Symbol (MGI) Tgfbr2tm1.2Hlm
Known defects Cleft palate, bone defects, small tongue
Known human diseases Loeys-Dietz Syndrome
Histology E18.5
SEM E18.5
μCT E18.5: soft – hard
3D μCT E18.5: soft – hard
μMRI E18.5: soft
Gene expression analysis E14.5
Protein expression analysis
References Ito Y et al., Development 2003
Sasaki T et al., Development 2006
Oka K et al., Dev Biol 2007
Oka K et al., Dev Biol 2008
Iwata J et al., J Biol Chem 2010
Iwata J et al., J Clin Invest 2012
Iwata J et al., J Biol Chem 2012 

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