Beta-catenin – MGI gene detail Description: Beta-catenin is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE at E14.5. Source: He et al. (2011) Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression. Dev. Biol. 350(2): 511-9….Continue Reading Beta-catenin gene expression
Category: Midline epithelium
Fgfr2 gene expression
Fgfr2 (Fibroblast growth factor receptor 2) – MGI gene detail Description: Fgfr2 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE. It is also expressed in the nasal mesenchyme at E13.5 only in the posterior region of the palatal shelf. Source: Snyder-Warwick et…Continue Reading Fgfr2 gene expression
Fgf9 gene expression
Fgf9 (Fibroblast growth factor 9) – MGI gene detail Description: Fgf9 is expressed in the palatal epithelium along the AP axis at E13.5. At E14.5, Fgf9 is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. Source: Iwata et al. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth…Continue Reading Fgf9 gene expression
Irf6 gene expression
Irf6 (Interferon regulatory factor 6) – MGI gene detail Description: Irf6 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE from E14.5 to E15.5. Source: Immunofluorescence. Unpublished data from Chai’s lab….Continue Reading Irf6 gene expression
Pitx2 gene expression
Pitx2 (Paired-like homeodomain transcription factor 2 / Pituitary homeobox 2) – MGI gene detail Description: At E13.5, Pitx2 is expressed in the palatal epithelium along the AP axis. At E14.5, Pitx2 is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. Source: Iwata et al. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2)…Continue Reading Pitx2 gene expression
Sox2 gene expression
Sox2 (SRY-box containing 2) – MGI gene detail Description: Sox2 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE from E14.5 to E15.5. Source: Immunofluorescence and Sox2-GFP knockin mice. Unpublished data from Chai’s lab….Continue Reading Sox2 gene expression
Tgfb3 gene expression
Tgfb3 (Transforming growth factor beta 3) – MGI gene detail Description: Tgfb3 is expressed in the midline epithelium before the palatal shelves have contact in the midline (E14.0) until the complete disappearance of the MEE (E15.5). Sources: Yang LT, Li LY & Kaartinen V, 2008. Tissue-specific expression of Cre recombinase from the Tgfb3 locus. Genesis 46(2):112-8. Jackson…Continue Reading Tgfb3 gene expression
Tbx1 gene expression
Tbx1 (T-box 1) – MGI gene detail Description: At E12.5, Tbx1 expression appears in the epithelium of the most posterior domain of the palatal shelf. Tbx1 is expressed in the medial and posterior edge of the secondary palate before and after fusion. Sources: Funato et al. (2012) Tbx1 regulates oral epithelial adhesion and palatal development. Hum. Mol. Genet. 21(11):2524-37….Continue Reading Tbx1 gene expression