Type III Collagen – MGI gene detail Description: Col III is expressed along the AP axis in the nasal and oral mesenchyme at E12.5 and then it is restricted to the oral mesenchyme from E13.5. Source: Immunostaining. Unpublished data from Chai’s lab….Continue Reading Col III gene expression
Category: Posterior region
Dlx5 gene expression
Dlx5 (Distal-less homeobox 5) – MGI gene detail Description: Dlx5 is expressed in the nasal mesenchyme along the AP axis of the E13.5 palatal shelf. Source: Han et al., 2009 Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development 136(24):4225-33….Continue Reading Dlx5 gene expression
Fgfr2 gene expression
Fgfr2 (Fibroblast growth factor receptor 2) – MGI gene detail Description: Fgfr2 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE. It is also expressed in the nasal mesenchyme at E13.5 only in the posterior region of the palatal shelf. Source: Snyder-Warwick et…Continue Reading Fgfr2 gene expression
Fgf9 gene expression
Fgf9 (Fibroblast growth factor 9) – MGI gene detail Description: Fgf9 is expressed in the palatal epithelium along the AP axis at E13.5. At E14.5, Fgf9 is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. Source: Iwata et al. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth…Continue Reading Fgf9 gene expression
Fgf7 gene expression
Fgf7 (Fibroblast growth factor 7) – MGI gene detail Description: At E12.5 and E13.5, Fgf7 is expressed in the mesenchyme along the AP axis and it is restricted to the nasal side. At E14.5, Fgf7 is expressed along the AP and ON axes of the palate. Sources: Han et al., 2009 Indirect modulation of Shh signaling by…Continue Reading Fgf7 gene expression
Gli1 gene expression
Gli1 – MGI gene detail Description: Gli1 is expressed in the oral mesenchyme and oral epithelium along the AP axis at E13.5. At E14.5, expression is restricted to the oral mesenchyme of the anterior region of the palate. Sources: Han et al. (2009) Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate…Continue Reading Gli1 gene expression
P-SMAD1/5/8
Phospho-SMAD 1/5/8 – MGI gene detail for Smad1, 5, 8 Description: Activation of BMP signaling is observed in the nasal mesenchyme of the palatal shelves at E13.5 and E14.5 along the AP axis. A few P-SMAD1/5/8-positive cells in the oral and nasal epithelia are also detectable (not depicted here). Source: Han et al. (2009) Indirect modulation…Continue Reading P-SMAD1/5/8
Pitx2 gene expression
Pitx2 (Paired-like homeodomain transcription factor 2 / Pituitary homeobox 2) – MGI gene detail Description: At E13.5, Pitx2 is expressed in the palatal epithelium along the AP axis. At E14.5, Pitx2 is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. Source: Iwata et al. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2)…Continue Reading Pitx2 gene expression
Runx2 gene expression
Runx2 (Runt-related transcription factor 2) – MGI gene detail Description: At E13.5 and E15.5, Runx2 is expressed in the osteogenic mesenchyme along the AP axis. Sources: Yamashiro et al. (2002) Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Mech. Dev. 119 Suppl 1:S107-10. Baek et al. (2011) Bmpr1a signaling plays critical roles in palatal…Continue Reading Runx2 gene expression
Tgfbr2 gene expression
Tgfbr2 (TGF-Beta receptor 2) – MGI gene detail Description: Tgfbr2 is expressed in both epithelium and mesenchyme along the oral-nasal and anterior-posterior axes at E13.5. Data at other stages is not available. Source: Radioactive in situ hybridization. Unpublished data from Chai’s lab….Continue Reading Tgfbr2 gene expression