Micro CT images (click to enlarge) E18.5 control E18.5 Msx1-/- The complete dataset can be downloaded at FaceBase.org…Continue Reading Msx1-/- E18.5 whole skull micro CTs
Category: Mouse
Msx1 gene expression
Msx1 (Msh homeobox 1) – MGI gene detail Description: Msx1 is expressed in the mesenchyme of the anterior region of the developing palate, on both nasal and oral sides. Sources:Zhang et al. (2002) Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian…Continue Reading Msx1 gene expression
Osr2 gene expression
Osr2 (Odd-skipped related 2) – MGI gene detail Description: Osr2 is expressed in the mesenchyme of the anterior region of the developing palate and it is restricted to the oral side. Source: Lan et al. (2004) Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development 131(13): 3207-16….Continue Reading Osr2 gene expression
P-SMAD1/5/8
Phospho-SMAD 1/5/8 – MGI gene detail for Smad1, 5, 8 Description: Activation of BMP signaling is observed in the nasal mesenchyme of the palatal shelves at E13.5 and E14.5 along the AP axis. A few P-SMAD1/5/8-positive cells in the oral and nasal epithelia are also detectable (not depicted here). Source: Han et al. (2009) Indirect modulation…Continue Reading P-SMAD1/5/8
Pitx2 gene expression
Pitx2 (Paired-like homeodomain transcription factor 2 / Pituitary homeobox 2) – MGI gene detail Description: At E13.5, Pitx2 is expressed in the palatal epithelium along the AP axis. At E14.5, Pitx2 is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. Source: Iwata et al. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2)…Continue Reading Pitx2 gene expression
Runx2 gene expression
Runx2 (Runt-related transcription factor 2) – MGI gene detail Description: At E13.5 and E15.5, Runx2 is expressed in the osteogenic mesenchyme along the AP axis. Sources: Yamashiro et al. (2002) Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Mech. Dev. 119 Suppl 1:S107-10. Baek et al. (2011) Bmpr1a signaling plays critical roles in palatal…Continue Reading Runx2 gene expression
Shox2 gene expression
Shox2 (Short stature homeobox gene 2) – MGI gene detail Description: Shox2 is expressed in the mesenchyme of the anterior region of the developing palate, on both nasal and oral sides. Source: Yu et al. (2005) Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development 132(19): 4397-406….Continue Reading Shox2 gene expression
Sox2 gene expression
Sox2 (SRY-box containing 2) – MGI gene detail Description: Sox2 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE from E14.5 to E15.5. Source: Immunofluorescence and Sox2-GFP knockin mice. Unpublished data from Chai’s lab….Continue Reading Sox2 gene expression
Tgfbr2 gene expression
Tgfbr2 (TGF-Beta receptor 2) – MGI gene detail Description: Tgfbr2 is expressed in both epithelium and mesenchyme along the oral-nasal and anterior-posterior axes at E13.5. Data at other stages is not available. Source: Radioactive in situ hybridization. Unpublished data from Chai’s lab….Continue Reading Tgfbr2 gene expression
Tgfb3 gene expression
Tgfb3 (Transforming growth factor beta 3) – MGI gene detail Description: Tgfb3 is expressed in the midline epithelium before the palatal shelves have contact in the midline (E14.0) until the complete disappearance of the MEE (E15.5). Sources: Yang LT, Li LY & Kaartinen V, 2008. Tissue-specific expression of Cre recombinase from the Tgfb3 locus. Genesis 46(2):112-8. Jackson…Continue Reading Tgfb3 gene expression