Dlx5 (Distal-less homeobox 5) – MGI gene detail Description: Dlx5 is expressed in the nasal mesenchyme along the AP axis of the E13.5 palatal shelf. Source: Han et al., 2009 Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development 136(24):4225-33….Continue Reading Dlx5 gene expression
Category: Transcription factors
Gli1 gene expression
Gli1 – MGI gene detail Description: Gli1 is expressed in the oral mesenchyme and oral epithelium along the AP axis at E13.5. At E14.5, expression is restricted to the oral mesenchyme of the anterior region of the palate. Sources: Han et al. (2009) Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate…Continue Reading Gli1 gene expression
Irf6 gene expression
Irf6 (Interferon regulatory factor 6) – MGI gene detail Description: Irf6 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE from E14.5 to E15.5. Source: Immunofluorescence. Unpublished data from Chai’s lab….Continue Reading Irf6 gene expression
Msx1 gene expression
Msx1 (Msh homeobox 1) – MGI gene detail Description: Msx1 is expressed in the mesenchyme of the anterior region of the developing palate, on both nasal and oral sides. Sources:Zhang et al. (2002) Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian…Continue Reading Msx1 gene expression
Osr2 gene expression
Osr2 (Odd-skipped related 2) – MGI gene detail Description: Osr2 is expressed in the mesenchyme of the anterior region of the developing palate and it is restricted to the oral side. Source: Lan et al. (2004) Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development 131(13): 3207-16….Continue Reading Osr2 gene expression
P-SMAD1/5/8
Phospho-SMAD 1/5/8 – MGI gene detail for Smad1, 5, 8 Description: Activation of BMP signaling is observed in the nasal mesenchyme of the palatal shelves at E13.5 and E14.5 along the AP axis. A few P-SMAD1/5/8-positive cells in the oral and nasal epithelia are also detectable (not depicted here). Source: Han et al. (2009) Indirect modulation…Continue Reading P-SMAD1/5/8
Pitx2 gene expression
Pitx2 (Paired-like homeodomain transcription factor 2 / Pituitary homeobox 2) – MGI gene detail Description: At E13.5, Pitx2 is expressed in the palatal epithelium along the AP axis. At E14.5, Pitx2 is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. Source: Iwata et al. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2)…Continue Reading Pitx2 gene expression
Runx2 gene expression
Runx2 (Runt-related transcription factor 2) – MGI gene detail Description: At E13.5 and E15.5, Runx2 is expressed in the osteogenic mesenchyme along the AP axis. Sources: Yamashiro et al. (2002) Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Mech. Dev. 119 Suppl 1:S107-10. Baek et al. (2011) Bmpr1a signaling plays critical roles in palatal…Continue Reading Runx2 gene expression
Shox2 gene expression
Shox2 (Short stature homeobox gene 2) – MGI gene detail Description: Shox2 is expressed in the mesenchyme of the anterior region of the developing palate, on both nasal and oral sides. Source: Yu et al. (2005) Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development 132(19): 4397-406….Continue Reading Shox2 gene expression
Sox2 gene expression
Sox2 (SRY-box containing 2) – MGI gene detail Description: Sox2 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE from E14.5 to E15.5. Source: Immunofluorescence and Sox2-GFP knockin mice. Unpublished data from Chai’s lab….Continue Reading Sox2 gene expression