Bmp4 (Bone morphogenetic protein 4) – MGI gene detail Description: Bmp4 is expressed in both epithelium and mesenchyme at E12.5. Its expression is restricted to the mesenchyme from E13.5. Bmp4 is expressed only in the anterior and distal regions of the palatal shelves. Source: Zhang et al. (2002) Rescue of cleft palate in Msx1-deficient mice by transgenic…Continue Reading Bmp4 gene expression
Category: Nasal epithelium
Beta-catenin gene expression
Beta-catenin – MGI gene detail Description: Beta-catenin is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE at E14.5. Source: He et al. (2011) Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression. Dev. Biol. 350(2): 511-9….Continue Reading Beta-catenin gene expression
Fgfr2 gene expression
Fgfr2 (Fibroblast growth factor receptor 2) – MGI gene detail Description: Fgfr2 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE. It is also expressed in the nasal mesenchyme at E13.5 only in the posterior region of the palatal shelf. Source: Snyder-Warwick et…Continue Reading Fgfr2 gene expression
Fgf9 gene expression
Fgf9 (Fibroblast growth factor 9) – MGI gene detail Description: Fgf9 is expressed in the palatal epithelium along the AP axis at E13.5. At E14.5, Fgf9 is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. Source: Iwata et al. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth…Continue Reading Fgf9 gene expression
Irf6 gene expression
Irf6 (Interferon regulatory factor 6) – MGI gene detail Description: Irf6 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE from E14.5 to E15.5. Source: Immunofluorescence. Unpublished data from Chai’s lab….Continue Reading Irf6 gene expression
P-SMAD1/5/8
Phospho-SMAD 1/5/8 – MGI gene detail for Smad1, 5, 8 Description: Activation of BMP signaling is observed in the nasal mesenchyme of the palatal shelves at E13.5 and E14.5 along the AP axis. A few P-SMAD1/5/8-positive cells in the oral and nasal epithelia are also detectable (not depicted here). Source: Han et al. (2009) Indirect modulation…Continue Reading P-SMAD1/5/8
Sox2 gene expression
Sox2 (SRY-box containing 2) – MGI gene detail Description: Sox2 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE from E14.5 to E15.5. Source: Immunofluorescence and Sox2-GFP knockin mice. Unpublished data from Chai’s lab….Continue Reading Sox2 gene expression
Tgfbr2 gene expression
Tgfbr2 (TGF-Beta receptor 2) – MGI gene detail Description: Tgfbr2 is expressed in both epithelium and mesenchyme along the oral-nasal and anterior-posterior axes at E13.5. Data at other stages is not available. Source: Radioactive in situ hybridization. Unpublished data from Chai’s lab….Continue Reading Tgfbr2 gene expression
Tbx1 gene expression
Tbx1 (T-box 1) – MGI gene detail Description: At E12.5, Tbx1 expression appears in the epithelium of the most posterior domain of the palatal shelf. Tbx1 is expressed in the medial and posterior edge of the secondary palate before and after fusion. Sources: Funato et al. (2012) Tbx1 regulates oral epithelial adhesion and palatal development. Hum. Mol. Genet. 21(11):2524-37….Continue Reading Tbx1 gene expression