Bmp4 (Bone morphogenetic protein 4) – MGI gene detail Description: Bmp4 is expressed in both epithelium and mesenchyme at E12.5. Its expression is restricted to the mesenchyme from E13.5. Bmp4 is expressed only in the anterior and distal regions of the palatal shelves. Source: Zhang et al. (2002) Rescue of cleft palate in Msx1-deficient mice by transgenic…Continue Reading Bmp4 gene expression
Category: Mouse
Beta-catenin gene expression
Beta-catenin – MGI gene detail Description: Beta-catenin is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE at E14.5. Source: He et al. (2011) Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression. Dev. Biol. 350(2): 511-9….Continue Reading Beta-catenin gene expression
Col III gene expression
Type III Collagen – MGI gene detail Description: Col III is expressed along the AP axis in the nasal and oral mesenchyme at E12.5 and then it is restricted to the oral mesenchyme from E13.5. Source: Immunostaining. Unpublished data from Chai’s lab….Continue Reading Col III gene expression
Dlx5 gene expression
Dlx5 (Distal-less homeobox 5) – MGI gene detail Description: Dlx5 is expressed in the nasal mesenchyme along the AP axis of the E13.5 palatal shelf. Source: Han et al., 2009 Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development 136(24):4225-33….Continue Reading Dlx5 gene expression
Microarray: E13.5 Erk2 Tongue
Whole-Genome Transcriptome Profiling by Microarray of Tongue Tissue of E13.5 Murine Embryos With and Without a Conditional Inactivation of Erk2 in the Cranial Neural Crest. See a heatmap of the top 10 most differentially expressed genes between mutant and control samples for the following signaling pathways: BMP/TGF-Beta signaling pathway FGF signaling pathway Hedgehog signaling pathway…Continue Reading Microarray: E13.5 Erk2 Tongue
Microarray: E13.5 Erk2 Palate
Whole-Genome Transcriptome Profiling by Microarray of Palatal Tissue of E13.5 Murine Embryos with and without a conditional inactivation of Erk2 in the cranial neural crest. See a heatmap of the top 10 most differentially expressed genes between mutant and control samples for the following signaling pathways: BMP/TGF-Beta signaling pathway FGF signaling pathway Hedgehog signaling pathway…Continue Reading Microarray: E13.5 Erk2 Palate
Microarray: E12.5 Erk2 Mandible
Whole-genome transcriptome profiling my microarray of mandibular tissue of E12.5 murine embryos with and without a conditional inactivation of Erk2 in the cranial neural crest See a heatmap of the top 10 most differentially expressed genes between mutant and control samples for the following signaling pathways: BMP/TGF-Beta signaling pathway FGF signaling pathway Hedgehog signaling pathway Wnt…Continue Reading Microarray: E12.5 Erk2 Mandible
Fgf10 gene expression
Fgf10 (Fibroblast growth factor 10) – MGI gene detail Description: Fgf10 is expressed in the mesenchyme of the anterior region of the developing palate and it is restricted to the oral side. Source: Alappat et al. (2005) The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev Biol 277(1): 102-13….Continue Reading Fgf10 gene expression
Fgfr2 gene expression
Fgfr2 (Fibroblast growth factor receptor 2) – MGI gene detail Description: Fgfr2 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE. It is also expressed in the nasal mesenchyme at E13.5 only in the posterior region of the palatal shelf. Source: Snyder-Warwick et…Continue Reading Fgfr2 gene expression
Fgf9 gene expression
Fgf9 (Fibroblast growth factor 9) – MGI gene detail Description: Fgf9 is expressed in the palatal epithelium along the AP axis at E13.5. At E14.5, Fgf9 is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. Source: Iwata et al. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth…Continue Reading Fgf9 gene expression