Category: Uncategorized

Genotype K14-Cre;Tgfbr2fl/fl Symbol (MGI) Tgfbr2tm1.2Hlm Known defects Submucosal cleft palate Known human diseases   Histology P0 SEM P0 μCT P0: soft – hard 3D μCT P0: soft – hard μMRI P0: soft Gene expression analysis   Protein expression analysis   References Iwata J. et al., Development 2013…Continue Reading Craniofacial phenotype analysis: K14-Cre;Tgfbr2fl/fl

Genotype Wnt1-Cre;Tgfbr2fl/fl Symbol (MGI) Tgfbr2tm1.2Hlm Known defects Cleft palate, bone defects, small tongue Known human diseases Loeys-Dietz Syndrome Histology E18.5 SEM E18.5 μCT E18.5: soft – hard 3D μCT E18.5: soft – hard μMRI E18.5: soft Gene expression analysis E14.5 Protein expression analysis   References Ito Y et al., Development 2003Sasaki T et al., Development 2006Oka K et al., Dev Biol…Continue Reading Craniofacial phenotype analysis: Wnt1-Cre;Tgfbr2fl/fl

Class III: Palatal shelves fail to meet at the midline Complete cleft of secondary palate Ctgf-/- K14-Cre;Shhfl/fl Wnt1-Cre;Alk5fl/fl Wnt1-Cre;Tgfbr2fl/fl Partial cleft of secondary palate: anterior K14-Cre;Alk5fl/fl K14-Cre;Tgfbr2fl/fl Shox2-/- Wnt1-Cre;Shox2fl/fl Partial cleft of secondary palate: posterior / cleft soft palate K14-Cre;Alk5fl/fl K14-Cre;Tgfbr2fl/fl Tbx1-/-…Continue Reading Class III cleft palate