Bmp4 (Bone morphogenetic protein 4) – MGI gene detail Description: Bmp4 is expressed in both epithelium and mesenchyme at E12.5. Its expression is restricted to the mesenchyme from E13.5. Bmp4 is expressed only in the anterior and distal regions of the palatal shelves. Source: Zhang et al. (2002) Rescue of cleft palate in Msx1-deficient mice by transgenic…Continue Reading Bmp4 gene expression
Category: Mesenchyme
Col III gene expression
Type III Collagen – MGI gene detail Description: Col III is expressed along the AP axis in the nasal and oral mesenchyme at E12.5 and then it is restricted to the oral mesenchyme from E13.5. Source: Immunostaining. Unpublished data from Chai’s lab….Continue Reading Col III gene expression
Dlx5 gene expression
Dlx5 (Distal-less homeobox 5) – MGI gene detail Description: Dlx5 is expressed in the nasal mesenchyme along the AP axis of the E13.5 palatal shelf. Source: Han et al., 2009 Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development 136(24):4225-33….Continue Reading Dlx5 gene expression
Fgf10 gene expression
Fgf10 (Fibroblast growth factor 10) – MGI gene detail Description: Fgf10 is expressed in the mesenchyme of the anterior region of the developing palate and it is restricted to the oral side. Source: Alappat et al. (2005) The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev Biol 277(1): 102-13….Continue Reading Fgf10 gene expression
Fgfr2 gene expression
Fgfr2 (Fibroblast growth factor receptor 2) – MGI gene detail Description: Fgfr2 is expressed in the palatal epithelium along the AP axis throughout development, including the oral and nasal epithelia and in the MEE. It is also expressed in the nasal mesenchyme at E13.5 only in the posterior region of the palatal shelf. Source: Snyder-Warwick et…Continue Reading Fgfr2 gene expression
Fgf9 gene expression
Fgf9 (Fibroblast growth factor 9) – MGI gene detail Description: Fgf9 is expressed in the palatal epithelium along the AP axis at E13.5. At E14.5, Fgf9 is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. Source: Iwata et al. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth…Continue Reading Fgf9 gene expression
Fgf7 gene expression
Fgf7 (Fibroblast growth factor 7) – MGI gene detail Description: At E12.5 and E13.5, Fgf7 is expressed in the mesenchyme along the AP axis and it is restricted to the nasal side. At E14.5, Fgf7 is expressed along the AP and ON axes of the palate. Sources: Han et al., 2009 Indirect modulation of Shh signaling by…Continue Reading Fgf7 gene expression
Gli1 gene expression
Gli1 – MGI gene detail Description: Gli1 is expressed in the oral mesenchyme and oral epithelium along the AP axis at E13.5. At E14.5, expression is restricted to the oral mesenchyme of the anterior region of the palate. Sources: Han et al. (2009) Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate…Continue Reading Gli1 gene expression
Msx1 gene expression
Msx1 (Msh homeobox 1) – MGI gene detail Description: Msx1 is expressed in the mesenchyme of the anterior region of the developing palate, on both nasal and oral sides. Sources:Zhang et al. (2002) Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian…Continue Reading Msx1 gene expression
Osr2 gene expression
Osr2 (Odd-skipped related 2) – MGI gene detail Description: Osr2 is expressed in the mesenchyme of the anterior region of the developing palate and it is restricted to the oral side. Source: Lan et al. (2004) Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development 131(13): 3207-16….Continue Reading Osr2 gene expression